Protein Details: Potassium voltage-gated channel subfamily S member 1

Protein ID

ICDB_Pro_0046

Protein Name

Potassium voltage-gated channel subfamily S member 1

Gene Name

KCNS1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Length

526 amino acids

AlphaFoldDB

AF-A4K2V2-F1-model_v4.pdb

Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2

Sequence

MLMLLVRGTHYENLRPKVVLPTPLVGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHREFEDLLSSVDGVSEASLETSRETSQEGRSADLESQAPSEPPHPQMY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1101/gr.6004607

RefSeq

NP_001162032.1; XP_009231898.1; XP_009231899.1